Fluoxetine for Dogs UK: An In-depth Guide

Nov 22, 2023 | Dog Behaviour

A landscape image illustrating a peaceful veterinarian clinic setting. In the foreground, a gentle, medium-sized dog is sitting calm

Understanding Fluoxetine for Dogs

What is Fluoxetine?

Fluoxetine for dogs UK, known as Prozac® or Reconcile®, is an SSRI antidepressant that has found its way into veterinary medicine due to its effectiveness in treating various behavioural issues in dogs. As an SSRI, fluoxetine works by increasing serotonin levels in the brain, a neurotransmitter that plays a key role in mood and behaviour.

Uses of Fluoxetine in Canine Behaviour

Fluoxetine is prescribed for a range of behaviour problems in dogs, notably separation anxiety, aggression, and obsessive-compulsive disorders. Its use has been pivotal in addressing behaviours that could otherwise lead to the euthanasia of pets, especially when these behaviours are dangerous or unacceptable.

In terms of specific behaviours, fluoxetine can be effective in managing:

  • Separation anxiety, where dogs exhibit distress and destructive behaviours in their owner’s absence.
  • Types of aggression, including fear aggression and aggression towards other dogs or humans.
  • Obsessive-compulsive behaviours, such as constant licking or tail chasing.
  • Trigger stacking in dogs, where multiple stressors accumulate and result in anxiety.

It’s important to note that while fluoxetine can help mitigate these behaviours, it’s most effective when used in conjunction with behavioural modification techniques.

This blog provides general information about Fluoxetine for dogs in the UK and is intended for educational purposes only. It is not veterinary advice and should not replace professional care. Always consult a qualified veterinarian for any medical or behavioural concerns with your pet. We do not accept liability for errors or the application of information found here. Your use of this blog acknowledges your understanding of these terms. If your pet is unwell, contact a veterinarian immediately.

Dosage and Administration

The dosage of fluoxetine for dogs typically ranges from 0.5 to 2 mg per kilogram of body weight, administered orally once a day under the guidance of a veterinarian. The exact dosage and duration of treatment depend on the specific condition and the dog’s response to the medication. It’s crucial to follow your veterinarian’s prescription and guidance, as abrupt changes or incorrect dosing can lead to adverse effects.

Key PointDescription
What is FluoxetineA selective serotonin reuptake inhibitor (SSRI) used to treat behaviour disorders in dogs
UsesTreats separation anxiety, aggression, generalized anxiety, and more
Dosage and AdministrationTypically 0.5 to 2 mg per kilogram of weight, once daily
Side EffectsCan include lethargy, insomnia, decreased appetite, and more serious effects like seizures
PrecautionsNot suitable for dogs with certain conditions or on specific medications
Veterinary OversightEssential for monitoring and adjusting treatment

Side Effects and Precautions

While fluoxetine is generally safe when prescribed by a veterinarian, it’s not devoid of side effects. Common side effects include lethargy, decreased appetite, insomnia, vomiting, and more. More severe side effects like seizures, tremors, and aggression warrant immediate veterinary attention.

It’s also important to consider certain precautions before starting fluoxetine. This medication is not recommended for dogs with a history of seizures, severe liver disease, or diabetes mellitus. Additionally, fluoxetine should not be used in dogs that are allergic to it, are under 6 months old, or are pregnant or lactating.

Certain medications, like MAO inhibitors and some anti-anxiety drugs, can adversely interact with fluoxetine, so it’s crucial to discuss your dog’s current medications with your veterinarian.

Commonly reported side effects with fluoxetine in dogs include:

  • weight loss
  • depression
  • lethargy, sleepiness
  • restlessness
  • panting
  • loss of appetite
  • vomiting
  • diarrhea

Weight loss can be a common side effect with fluoxetine when used in dogs. Studies with Reconcile (fluoxetine) chewable tablets have shown weight loss occurred in 29.6% (58 / 196) of dogs treated with fluoxetine and 13% (24 / 185) of dogs in the control group.

In studies, dogs who lost weight most frequently lost 5% to 10% of their initial weight (22.5% of the fluoxetine group and 10.8% of the control group).

Serious side effects may include:

  • seizures
  • tremors
  • persistent weight loss or loss of appetite
  • disinhibition of aggressive behaviour
  • ongoing restless or inability to sleep
  • serotonin syndrome

The Importance of Veterinary Oversight

Ongoing veterinary oversight is crucial when your dog is on fluoxetine. Although regular monitoring may not be necessary, it’s essential to consult your vet if any adverse side effects occur. The vet will also guide you on the correct dosage and the duration of treatment. Never administer fluoxetine without a vet’s prescription, and avoid self-adjusting the dose or discontinuing the medication abruptly.

Fluoxetine’s Role in Comprehensive Behaviour Therapy

While fluoxetine can be a valuable tool in managing canine behavioural issues, it’s most effective as part of a comprehensive behavioural therapy plan. This may include training techniques that focus on reactive dog training or understanding and managing specific behaviours like resource guarding and fear aggression. Combining medication with behaviour modification enhances the chances of successfully managing and even resolving problematic behaviours.

In the United Kingdom, fluoxetine for dogs is a prescription-only medication. This means it must be prescribed by a licensed veterinarian. While the active ingredient in fluoxetine is the same as in human medications like Prozac and Sarafem, the veterinary formulations, such as Reconcile, are specifically tailored for canine use. It’s important for dog owners to understand that they cannot simply use human fluoxetine for their pets without a vet’s prescription and guidance.

Sourcing Fluoxetine for Dogs in the UK

When sourcing fluoxetine in the UK, it’s crucial to go through legitimate channels, typically your veterinarian or a licensed pharmacy. The medication comes in various forms, including tablets, capsules, and liquid, with different strengths to suit individual needs. Adherence to storage instructions – keeping the medication at room temperature away from moisture and light – is vital for maintaining its efficacy.

Cost Considerations

The cost of fluoxetine can vary, depending on the dosage and the duration of treatment. Dog owners should discuss the potential costs with their veterinarian to budget accordingly. It’s also worth considering that while medication might have an upfront cost, effective treatment can lead to a better quality of life for both the dog and the owner.

The Role of Fluoxetine in Dog Behaviour Management

Fluoxetine represents a significant advancement in managing canine behavioural disorders. It offers hope for dogs struggling with issues like separation anxiety and aggression, which, left untreated, can strain the human-animal bond and even lead to euthanasia in severe cases.

However, it’s imperative to remember that medication is just one piece of the puzzle. A holistic approach that includes behavioural modification, understanding the dog’s emotional needs, and consistent training is essential for long-term success.

For specific, situational medication for issues relating to fear of noises, Sileo is a good option too.

Seeking Professional Help

If you’re considering fluoxetine for your dog, the first step is to consult with a veterinarian. They can provide a comprehensive assessment, prescribe the appropriate medication, and offer guidance on behavioural modification techniques. Remember, addressing behavioural issues in dogs is a journey that requires patience, understanding, and commitment.

Final Thoughts: Embracing a Comprehensive Approach

In conclusion, fluoxetine for dogs UK can be a valuable tool in the arsenal for managing canine behaviour issues, particularly in the UK where it is strictly regulated and prescribed. It’s important to remember that while fluoxetine can assist in managing symptoms, it is not a cure-all. Successful behaviour modification in dogs often requires a combination of medication, training, and a deep understanding of canine psychology.

Key Recommendations for Dog Owners:

  • Consultation is Key:

    Always begin with a consultation with a qualified veterinarian. They can assess whether fluoxetine is suitable for your dog’s specific needs.

  • Combine Treatments:

    Use fluoxetine as part of a broader behavioural management plan. This might include training programmes that focus on specific issues like aggression or anxiety.

  • Follow Professional Advice:

    Adhere strictly to the prescribed dosage and schedule. Never modify the dose or discontinue the medication without consulting your veterinarian.

  • Monitor and Adjust:

    Be vigilant for side effects and communicate with your veterinarian for any adjustments or concerns.

  • Patience and Consistency:

    Behavioural change takes time. Be patient and consistent with the treatment and training plan.

Navigating the Journey with Your Dog

Dealing with behaviour issues in dogs can be challenging, but with the right approach, significant improvements are possible. Whether it’s tackling separation anxiety, aggression, or other behaviour concerns, remember that you’re not alone.

The Role of a Responsible Pet Owner

As a pet owner, your role in your dog’s behavioural management is crucial. Understanding the intricacies of medications like fluoxetine, being aware of the behavioural signs to watch for, and actively participating in training and behaviour modification processes are all part of responsible pet ownership.

Final Takeaway

Fluoxetine for dogs in the UK is a testament to the advancements in veterinary medicine and animal behaviour management. It opens up new possibilities for treating complex behavioural issues, thereby enhancing the quality of life for both dogs and their owners.

About Me

Jim Gillies, a Certified Dog Behaviourist and Trainer in Glasgow with over 10 years of experience, prioritises canine well-being through modern, science-backed methods. Handling 4000+ cases of 1-to-1 behaviour training, Jim is fully accredited, insured, and recognised for addressing various behavioural issues including aggression, separation anxiety, and more. Jim holds qualifications in level 5 (merit) Advance Diploma Canine Behaviour Management and level 6 Applied Animal Behaviour. Explore his insightful blog and podcast, sharing expert knowledge on dog training and behaviour. Certified by the IAABC, Jim’s expertise makes him a reliable choice for addressing your dog’s needs.

Contact Information

Should you have any questions about this article, feel free to contact me on:

Email: jim@cbtdogbehaviour.com

Mobile: 07864029933


Please note that I am an Amazon Affiliate, and the products recommended in this guide are sold on Amazon. For each product listed, I have provided a hyperlink that directs you to the Amazon page where you can make a purchase. Should you decide to buy any of the products through the provided links, I will earn a small commission at no additional cost to you. This affiliate commission helps to support my work and continue providing valuable information to my readers. Thank you for your support!

Fluoxetine for Dogs UK

FAQ: Fluoxetine for Dogs UK

1. Is 40mg of Fluoxetine a High Dose for Dogs?
40mg can be considered a high dose for smaller dogs but may be appropriate for larger breeds. The exact dosage depends on the dog’s weight and the condition being treated. Always consult a veterinarian for the correct dosage.
2. Where Can I Buy Fluoxetine for Dogs in the UK?
Fluoxetine for dogs in the UK requires a prescription and can be purchased at veterinary clinics or licensed pharmacies.
3. Can You Open Fluoxetine Capsules for Dogs?
It’s not recommended to open fluoxetine capsules for dogs as this can alter the dosage and effectiveness. Always use the medication as prescribed by your vet.
4. How Long for Fluoxetine to Work in Dogs?
Fluoxetine may take 3 to 4 weeks to show noticeable effects in dogs, and sometimes up to 8 weeks for full effectiveness.
5. How Many Mg of Fluoxetine for Dogs?
The typical dosage of fluoxetine for dogs is 0.5 to 2 mg per kilogram of body weight, given once daily. Exact dosages should be determined by a vet.
6. How Much Does Fluoxetine for Dogs Cost?
The cost of fluoxetine for dogs varies based on dosage, formulation, and location. Discuss with your vet for specific pricing.
7. How Much Fluoxetine for Dogs?
The amount of fluoxetine for dogs typically ranges from 0.5 to 2 mg per kilogram of weight daily. Your vet will provide the exact amount needed for your dog’s specific condition.
8. Is Fluoxetine for Dogs the Same as for Humans?
While the active ingredient is the same, fluoxetine formulations and dosages for dogs are different from those for humans. It’s important to use the veterinary-specific formulation.
9. Is Fluoxetine Safe for Dogs?
Fluoxetine is generally safe for dogs when prescribed by a veterinarian and used as directed.
10. What Does Fluoxetine Do for Dogs?
Fluoxetine helps manage behavioral issues in dogs, such as aggression, separation anxiety, and obsessive-compulsive disorders.
11. What Dose of Fluoxetine for Dogs?
The dose of fluoxetine for dogs is typically 0.5 to 2 mg per kilogram of body weight, given once daily.
12. What is Fluoxetine Used for in Dogs?
Fluoxetine is used to treat various behavioral problems in dogs, including separation anxiety, aggression, and obsessive-compulsive disorders.
13. Where to Buy Fluoxetine for Dogs?
Fluoxetine can be purchased at veterinary clinics or licensed pharmacies in the UK, but only with a prescription from a veterinarian.
14. Can Humans Take Fluoxetine for Dogs?
Fluoxetine for dogs should not be taken by humans as the dosages and formulations are specific to canine physiology.
15. Does Fluoxetine Work for Dogs?
Fluoxetine has been shown to be effective for many dogs in treating behavioral issues when used as part of a comprehensive treatment plan.
16. How Much Fluoxetine for Aggressive Dogs?
The amount of fluoxetine for aggressive dogs depends on the dog’s weight and the severity of the aggression. Veterinarian guidance is essential.
17. Where Can I Buy Fluoxetine 20 mg for My Dog?
Fluoxetine 20 mg for dogs can be purchased from a veterinary clinic or a licensed pharmacy in the UK with a prescription.
18. Where Can I Get Fluoxetine for Dogs?
You can obtain fluoxetine for your dog from a veterinary clinic or a licensed pharmacy in the UK with a valid prescription.


Simpson BS, Landsberg GM, Reisner IR, et al. (2007).
Effects of Reconcile (fluoxetine) chewable tablet plus behavior management for canine separation anxiety. Vet Ther, 8(1):18-31.
Toxicity Study D3760 (2007).
A One Year Chronic Toxicity Study with Two Month Recovery Phase of Fluoxetine Hydrochloride (LY110140) Administered Orally to Beagle Dogs. Freedom of Information Summary NADA 141-272; Reconcile Fluoxetine Hydrochloride Chewable Tablets: Dogs.
Field Study T8E420001 (2007).
Efficacy Evaluation of Fluoxetine (fluoxetine hydrochloride) for the Control of Separation Anxiety in Dogs. Freedom of Information Summary NADA 141-272; Reconcile Fluoxetine Hydrochloride Chewable Tablets: Dogs.
Reconcile Chewable Tablets for Dogs.
Summary of Product Characteristics (2021).

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